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Astrocyte glutamate transporters are increased in an early sporadic model of synucleinopathy.

Diniz, Luan Pereira; Araujo, Ana Paula Bérgamo; Matias, Isadora; Garcia, Matheus N.; Barros-Aragão, Fernanda G.Q.; De melo Reis, Ricardo Augusto; Foguel, Débora; Braga, Carolina; Figueiredo, Cláudia P. ; Romão, Luciana; Gomes, Flávia Carvalho Alcantara.

Modulation in phase and frequency of neural oscillations during epileptiform activity induced by neonatal Zika virus infection in mice.

Daniel J. L. L. Pinheiro, Leandro F. Oliveira, Isis N. O. Souza, João A. Ferres Brogin, Douglas D. Bueno, Iranaia Assunção Miranda, Andrea T. Da Poian, Sergio T. Ferreira, Claudia P. Figueiredo, Julia R. Clarke, Esper A. Cavalheiro & Jean Faber.

Palmitate Is Increased in the Cerebrospinal Fluid of Humans with Obesity and Induces Memory Impairment in Mice via Pro-inflammatory TNF-α.

Helen M. Melo, Gisele da S. Seixas da Silva, Marcella Ramos Sant’Ana, Camila Vieira Ligo Teixeira , Julia R. Clarke, Vivian S. Miya Coreixas, Bruno C. de Melo Juliana T.S. Fortuna, Leticia Forny-Germano, José Henrique Ledo, Maíra S. Oliveira, Claudia P. Figueiredo, Raphaelle Pardossi-Piquard, Frédéric Checler, José María Delgado-García, Agnès Gruart Licio A. Velloso, Marcio L.F. Balthazar, Dennys E. Cintra, Sergio T. Ferreira, Fernanda G. De Felice.

Red wine consumption mitigates the cognitive impairments in low-density lipoprotein receptor knockout  (LDLr −/− )  mice.

Gabriela Cristina De Paula, Jade de Oliveira, Daiane Fátima Engel, Samantha Cristiane Lopes ,Eduardo Luiz Gasnhar Moreira, Claudia Pinto Figueiredo, Rui Daniel Prediger, Andreza Fabro de Bem.

Skeletal muscle is an early site of Zika virus replication and injury impairing myogenesis.

Gavino-Leopoldino, Daniel; Figueiredo, Camila Menezes; Da Silva Mariana Oliveira Lopes; Barcellos, Letícia Gonçalves; Neris Rômulo Leão Silva; Pinto, Laryssa Daniele Miranda; Araújo, Suzana Maria Bernardino; Leandro Ladislau; Benjamim, Claudia Farias; Da Poian, Andrea T.; Clarke, Julia Rosauro; Figueiredo, Claudia Pinto; Assunção-Miranda, Iranaia.

Innate immune memory mediates increased susceptibility to Alzheime-s disease-like pathology in sepsis surviving mice.

Virginia L .De Sousa; Suzana B. Araújo; Leticia M. Antonio; Mariana Silva-Queiroz; Lilian C. Colodeti; Carolina Soares; Fernanda Barros-Aragão; Hannah P. Mota-Araujo; Vinícius S. Alves; Robson Coutinho-Silva; Luiz Eduardo B. Savio; Sergio T. Ferreira; Robson Da Costa; Julia R. Clarke; Claudia P. Figueiredo.

Antileishmanial Chemotherapy through Clemastine Fumarate Mediated Inhibition of the Leishmania Inositol Phosphorylceramide Synthase. ACS Infectious Diseases.

John G. M. Mina, Rebecca L. Charlton, Edubiel Alpizar-Sosa, Douglas O. Escrivani, Christopher Brown, Amjed Alqaisi, Maria Paula G. Borsodi, Claudia P. Figueiredo, Emanuelle V. de Lima, Emily A. Dickie, Wenbin Wei, Robson Coutinho-Silva, Andy Merritt, Terry K. Smith, Michael P. Barrett, Bartira Rossi-Bergmann, Paul W. Denny, and Patrick G. Steel.

Dissociation of genotype-dependent cognitive and motor behavior in a strain of aging mice devoid of the prion protein.

Daiane R. Janner; Emanuelle V.de Lima; Rachel T. da Silva; Julia R. Clarke; Rafael Linden.

Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral 2 metabolic alterations in Alzheimer’s disease.

Natalia M. Lyra e Silva, Rafaella A. Gonçalves, Tharick A. Pascoal, Ricardo A. S. Lima-Filho, Elisa de Paula França Resende, Erica L. M. Vieira, Antonio L. Teixeira, Leonardo C. de Souza, Julyanna A. Peny, Juliana T. S. Fortuna, Isadora C. Furigo, Debora Hashiguchi, Vivian S. Miya-Coreixas, Julia R. Clarke, Jose F. Abisambra, Beatriz M. Longo, Jose Donato Jr., Paul E. Fraser, Pedro Rosa-Neto, Paulo Caramelli, Sergio T. Ferreira, Fernanda G. De Felice.

Taxane-induced neurotoxicity: Pathophysiology and therapeutic perspectives.

Robson Costa, Giselle F. Passos, Nara L. M. Quintão, Elizabeth S. Fernandes, João Raphael L.C.B. Maia, Maria M. Campos, João B. Calixto.

Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models.

Lourenco MV, Frozza RL, de Freitas GB, Zhang H, Kincheski GC, Ribeiro FC, Gonçalves RA, ClarkeJR, Beckman D, Staniszewski A, Berman H, Guerra LA, Forny-Germano L, Meier S, Wilcock DM, de Souza JM, Alves-Leon S, Prado VF, Prado MAM, Abisambra JF, Tovar-Moll F, Mattos P, Arancio O, Ferreira ST, De Felice FG.

Late Cognitive Consequences of Gestational Diabetes to the Offspring, in a New Mouse Model.

Ricardo A.L. De Sousa, Emanuelle V Lima, Tamara P. Silva, Renata V. Souza,  Claudia P. Figueiredo, Giselle F Passos, Julia H.R. Clarke.

Promiscuous G-protein coupled receptor inhibition of transient receptor potential melastatin 3 ion channels by Gβγ subunits.

Alkhatib O, Costa R, Gentry C, Quallo T, Bevan S, Andersson DA.

Pharmacological Treatment of Chemotherapy-Induced Neuropathic Pain: PPARγ Agonists as a Promising Tool.

Quintão NLM, Santin JR, Stoeberl LC, Corrêa TP, Melato J, Costa R.

The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice.

Dias FC, Alves VS, Matias DO, Figueiredo CP, Miranda ALP, Passos GF, Costa R.

Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice.

Manjavachi MN, Passos GF, Trevisan G, Araújo SB, Pontes JP, Fernandes ES, Costa R, Calixto JB.

Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice.

Pereira DMS, Mendes SJF, Alawi K, Thakore P, Aubdool A, Sousa NCF, da Silva JFR, Castro JA Jr, P Pereira IC, Silva LCN, Grisotto MAG, Monteiro-Neto V, Costa SKP, da Costa R, Calixto JB, Brain SD, Fernandes ES.

Acute and chronic neurological consequences of early-life Zika virus infection in mice.

Nem de Oliveira Souza I, Frost PS, França JV, Nascimento-Viana JB, Neris RLS, Freitas L, Pinheiro DJLL, Nogueira CO, Neves G, Chimelli L, De Felice FG, Cavalheiro ÉA, Ferreira ST, Assunção-Miranda I, Figueiredo CP, Da Poian AT, Clarke JR.

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease.

Batista AF, Forny-Germano L, Clarke JR, Lyra E Silva NM, Brito-Moreira J, Boehnke SE, Winterborn A, Coe BC, Lablans A, Vital JF, Marques S, Martinez AM, Gralle M, Holscher C, Klein WL, Houzel JC, Ferreira ST, Munoz DP, De Felice FG.

Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice.

Segat GC, Manjavachi MN, Matias DO, Passos GF, Freitas CS, Costa R, Calixto JB.

Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer’s Disease.

Irina Petrushina, Hayk Davtyan, Armine Hovakimyan, Arpine Davtyan, Giselle F. Passos, David H. Cribbs, Anahit Ghochikyan, Michael G. Agadjanyan.

Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches.

Clarke JR, Ribeiro FC, Frozza RL, De Felice FG, Lourenco MV.

Consequences of gestational diabetes to the brain and behavior of the offspring.

Sousa, R.A.L.; Torres, Y.S.; Figueiredo, C.P.; Passos, G.F.; Clarke, J.R.

Interaction of Aβ Oligomers with Neurexin 2α and Neuroligin 1 Mediates Synapse Damage and Memory Loss in Mice.

Brito-Moreira J, Lourenco MV, Oliveira MM, Vital JF, Ribeiro FC, Ledo JH, Diniz LP, Magdesian MH, Melo HM, Barros-Aragão F, de Souza JM, Alves-Leon SV, Gomes FC, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST.

Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats.

Bitencourt RM, Guerra de Souza AC, Bicca MA, Pamplona FA, de Mello N, Passos GF, Medeiros R, Takahashi RN, Calixto JB, Prediger RD. 

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.

Kincheski GC, Valentim IS, Clarke JR, Cozachenco D, Castelo-Branco MTL, Ramos-Lobo AM, Rumjanek VMBD, Donato J Jr, De Felice FG, Ferreira ST.

Kinin Receptors Sensitize TRPV4 Channel and Induce Mechanical Hyperalgesia: Relevance to Paclitaxel-Induced Peripheral Neuropathy in Mice.

Costa R, Bicca MA, Manjavachi MN, Segat GC, Dias FC, Fernandes ES, Calixto JB.

The transient receptor potential ankyrin-1 mediates mechanical hyperalgesia induced by the activation of B1 receptor in mice.

Meotti FC, Figueiredo CP, Manjavachi M, Calixto JB.

Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.

Neves FS, Marques PT, Barros-Aragão F, Nunes JB, Venancio AM, Cozachenco D, Frozza RL, Passos GF, Costa R, de Oliveira J, Engel DF, De Bem AF, Benjamim CF, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP.

Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms.

Mendes, S. J. F. ; Italiano, F. ; Pereira, D. M. S. ; Ferro, T. F. ; Pereira, I. C. P. ; Silva, B. L. R. ; Monteiro-Neto, V. ; Costa, S. K. P. ; Nascimento, J. L. M. ; Grisotto, M. A. G. ; Costa, R. ; Fernandes, Elizabeth S . 

Atheroprotective action of a modified organoselenium compound: in vitro evidence.

Oliveira J, Straliotto MR, Mancini G, Figueiredo CP, Braga AL, Teixeira JB, Bem AF.

The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε.

Dutra, R. C. ; Silva, K. A. B. S. ; Bicca, M. A. ; Segat, G.C. ; Motta, E. M. ; Pianowski, L. F. ; Costa, R. ; Calixto, J. B. .

Experimental hypertension increases spontaneous intracerebral hemorrhages in a mouse model of cerebral amyloidosis.

Passos GF, Kilday K, Gillen DL, Cribbs DH, Vasilevko V. 

The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε.

Dutra RC, Bicca MA, Segat GC, Silva KA, Motta EM, Pianowski LF, Costa R, Calixto JB.

Capsular Contracture In Silicone Breast Implants: Insights From Rat Models.

Vieira VJ, D'Acampora A, Neves FS, Mendes PR, Vasconcellos ZA, Neves RD, Figueiredo CP.

Temporal and Regional Expression of Glucose-Dependent Insulinotropic Peptide and Its Receptor in Spinal Cord Injured Rats.

Marcos AB, Forner S, Martini AC, Patrício ES, Clarke JR, Costa R, Felix-Alves J, Vieira VJ, de Andrade EL, Mazzuco TL, Calixto JB, Figueiredo CP. 

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG.

Transplantation of Human Skin-Derived Mesenchymal Stromal Cells Improves Locomotor Recovery After Spinal Cord Injury in Rats.

Vieira Melo FR, Bressan RB, Forner S, Martini AC, Rode M, Delben PB, Rae GA, Figueiredo CP, Trentin AG. , D'Acampora A, Neves FS, Mendes PR, Vasconcellos ZA, Neves RD, Figueiredo CP.

Mechanisms Underlying the Scratching Behavior Induced by the Activation of Proteinase-Activated Receptor-4 in Mice.

Patricio ES, Costa R, Figueiredo CP, Gers-Barlag K, Bicca MA, Manjavachi MN, Segat GC, Gentry C, Luiz AP, Fernandes ES, Cunha TM, Bevan S, Calixto JB. 

Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles.

Figueiredo CP, Ferreira NC, Passos GF, Costa Rd, Neves FS, Machado CS, Mascarello A, Chiaradia-Delatorre LD, Neuenfeldt PD, Nunes RJ, Cordeiro Y.

B₂ receptor blockage prevents Aβ-induced cognitive impairment by neuroinflammation inhibition.

Bicca MA, Costa R, Loch-Neckel G, Figueiredo CP, Medeiros R, Calixto JB.

Mechanisms Underlying the Scratching Behavior Induced by the Activation of Proteinase-Activated Receptor-4 in Mice.

Patricio ES, Costa R, Figueiredo CP, Gers-Barlag K, Bicca MA, Manjavachi MN, Segat GC, Gentry C, Luiz AP, Fernandes ES, Cunha TM, Bevan S, Calixto JB. 

The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice.

Manjavachi MN, Costa R, Quintão NL, Calixto JB. 

Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.

Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs DH, LaFerla FM

Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease.

Ferreira ST, Clarke JR, Bomfim TR, De Felice FG.

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. 

Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST.

The bradykinin B1 receptor regulates Aβ deposition and neuroinflammation in Tg-SwDI mice.

Passos GF, Medeiros R, Cheng D, Vasilevko V, Laferla FM, Cribbs DH. 

The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice.

Passos GF, Medeiros R, Marcon R, Nascimento AF, Calixto JB, Pianowski LF. 

Probucol affords neuroprotection in a 6-OHDA mouse model of Parkinson's disease.

Ribeiro RP, Moreira EL, Santos DB, Colle D, Dos Santos AA, Peres KC, Figueiredo CP, Farina M.