Promiscuous G-protein coupled receptor inhibition of transient receptor potential melastatin 3 ion channels by Gβγ subunits

Pharmacological Treatment of Chemotherapy-Induced Neuropathic Pain: PPARγ Agonists as a Promising Tool.

Spinal blockage of CXCL1 and its receptor CXCR2 inhibits paclitaxel-induced peripheral neuropathy in mice.

The selective TRPV4 channel antagonist HC-067047 attenuates mechanical allodynia in diabetic mice.


Transient Receptor Potential Canonical Channels 4 and 5 Mediate Escherichia coli-Derived Thioredoxin Effects in Lipopolysaccharide-Injected Mice.

Antiallodynic effect of β-caryophyllene on paclitaxel-induced peripheral neuropathy in mice.

The diabetes drug liraglutide reverses cognitive impairment in mice and attenuates insulin receptor and synaptic pathology in a non-human primate model of Alzheimer's disease

Metabolic Dysfunction in Alzheimer's Disease: From Basic Neurobiology to Clinical Approaches.


Comparison of Efficacy of Preventive and Therapeutic Vaccines Targeting the N Terminus of β-Amyloid in an Animal Model of Alzheimer’s Disease.

Irina Petrushina, Hayk Davtyan, Armine Hovakimyan, Arpine Davtyan, Giselle F. Passos, David H. Cribbs, Anahit Ghochikyan, Michael G. Agadjanyan.

Consequences of gestational diabetes to the brain and behavior of the offspring

Sousa, R.A.L.; Torres, Y.S.; Figueiredo, C.P.; Passos, G.F.; Clarke, J.R.

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice.

Kincheski GC, Valentim IS, Clarke JR, Cozachenco D, Castelo-Branco MTL, Ramos-Lobo AM, Rumjanek VMBD, Donato J Jr, De Felice FG, Ferreira ST.

Interaction of Aβ Oligomers with Neurexin 2α and Neuroligin 1 Mediates Synapse Damage and Memory Loss in Mice.

Brito-Moreira J, Lourenco MV, Oliveira MM, Vital JF, Ribeiro FC, Ledo JH, Diniz LP, Magdesian MH, Melo HM, Barros-Aragão F, de Souza JM, Alves-Leon SV, Gomes FC, Clarke JR, Figueiredo CP, De Felice FG, Ferreira ST.

The transient receptor potential ankyrin-1 mediates mechanical hyperalgesia induced by the activation of B1 receptor in mice.

Meotti FC, Figueiredo CP, Manjavachi M, Calixto JB.

Kinin Receptors Sensitize TRPV4 Channel and Induce Mechanical Hyperalgesia: Relevance to Paclitaxel-Induced Peripheral Neuropathy in Mice

Costa R, Bicca MA, Manjavachi MN, Segat GC, Dias FC, Fernandes ES, Calixto JB.

Blockade of hippocampal bradykinin B1 receptors improves spatial learning and memory deficits in middle-aged rats.

Bitencourt RM, Guerra de Souza AC, Bicca MA, Pamplona FA, de Mello N, Passos GF, Medeiros R, Takahashi RN, Calixto JB, Prediger RD. 


Brain-Defective Insulin Signaling Is Associated to Late Cognitive Impairment in Post-Septic Mice.

Neves FS, Marques PT, Barros-Aragão F, Nunes JB, Venancio AM, Cozachenco D, Frozza RL, Passos GF, Costa R, de Oliveira J, Engel DF, De Bem AF, Benjamim CF, De Felice FG, Ferreira ST, Clarke JR, Figueiredo CP.

The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε.

Dutra, R. C. ; Silva, K. A. B. S. ; Bicca, M. A. ; Segat, G.C. ; Motta, E. M. ; Pianowski, L. F. ; Costa, R. Calixto, J. B. .

Cinnamaldehyde modulates LPS-induced systemic inflammatory response syndrome through TRPA1-dependent and independent mechanisms

Mendes, S. J. F. ; Italiano, F. ; Pereira, D. M. S. ; Ferro, T. F. ; Pereira, I. C. P. ; Silva, B. L. R. ; Monteiro-Neto, V. ; Costa, S. K. P. ; Nascimento, J. L. M. ; Grisotto, M. A. G. ; Costa, R. ; Fernandes, Elizabeth S . 

The antinociceptive effects of the tetracyclic triterpene euphol in inflammatory and neuropathic pain models: The potential role of PKCε.

Dutra RC, Bicca MA, Segat GC, Silva KA, Motta EM, Pianowski LF, Costa R, Calixto JB.

Experimental hypertension increases spontaneous intracerebral hemorrhages in a mouse model of cerebral amyloidosis.

Passos GF, Kilday K, Gillen DL, Cribbs DH, Vasilevko V. 

Atheroprotective action of a modified organoselenium compound: in vitro evidence.

Oliveira J, Straliotto MR, Mancini G, Figueiredo CP, Braga AL, Teixeira JB, Bem AF.

Capsular Contracture In Silicone Breast Implants: Insights From Rat Models.

Vieira VJ, D'Acampora A, Neves FS, Mendes PR, Vasconcellos ZA, Neves RD, Figueiredo CP.

Transplantation of Human Skin-Derived Mesenchymal Stromal Cells Improves Locomotor Recovery After Spinal Cord Injury in Rats.

Melo FR, Bressan RB, Forner S, Martini AC, Rode M, Delben PB, Rae GA, Figueiredo CP, Trentin AG. 

Temporal and Regional Expression of Glucose-Dependent Insulinotropic Peptide and Its Receptor in Spinal Cord Injured Rats.

Marcos AB, Forner S, Martini AC, Patrício ES, Clarke JR, Costa R, Felix-Alves J, Vieira VJ, de Andrade EL, Mazzuco TL, Calixto JB, Figueiredo CP


Toxicological Evaluation of Anti-Scrapie Trimethoxychalcones and Oxadiazoles.

Figueiredo CP, Ferreira NC, Passos GF, Costa Rd, Neves FS, Machado CS, Mascarello A, Chiaradia-Delatorre LD, Neuenfeldt PD, Nunes RJ, Cordeiro Y.

Mechanisms Underlying the Scratching Behavior Induced by the Activation of Proteinase-Activated Receptor-4 in Mice.

Patricio ES, Costa R, Figueiredo CP, Gers-Barlag K, Bicca MA, Manjavachi MN, Segat GC, Gentry C, Luiz AP, Fernandes ES, Cunha TM, Bevan S, Calixto JB. 

Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation.

Clarke JR, Lyra E Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, Silveira MA, Ribeiro FC, Bomfim TR, Neves FS, Klein WL, Medeiros R, LaFerla FM, Carvalheira JB, Saad MJ, Munoz DP, Velloso LA, Ferreira ST, De Felice FG.

B₂ receptor blockage prevents Aβ-induced cognitive impairment by neuroinflammation inhibition.

Bicca MA, Costa R, Loch-Neckel G, Figueiredo CP, Medeiros R, Calixto JB.


Inflammation, defective insulin signaling, and neuronal dysfunction in Alzheimer's disease.

Ferreira ST, Clarke JR, Bomfim TR, De Felice FG. 

The role of keratinocyte-derived chemokine (KC) on hyperalgesia caused by peripheral nerve injury in mice.

Manjavachi MN, Costa R, Quintão NL, Calixto JB. 


Memantine rescues transient cognitive impairment caused by high-molecular-weight aβ oligomers but not the persistent impairment induced by low-molecular-weight oligomers.

Figueiredo CP, Clarke JR, Ledo JH, Ribeiro FC, Costa CV, Melo HM, Mota-Sales AP, Saraiva LM, Klein WL, Sebollela A, De Felice FG, Ferreira ST.

TNF-α mediates PKR-dependent memory impairment and brain IRS-1 inhibition induced by Alzheimer's β-amyloid oligomers in mice and monkeys.

Lourenco MV, Clarke JR, Frozza RL, Bomfim TR, Forny-Germano L, Batista AF, Sathler LB, Brito-Moreira J, Amaral OB, Silva CA, Freitas-Correa L, Espírito-Santo S, Campello-Costa P, Houzel JC, Klein WL, Holscher C, Carvalheira JB, Silva AM, Velloso LA, Munoz DP, Ferreira ST, De Felice FG. 

Aspirin-triggered lipoxin A4 stimulates alternative activation of microglia and reduces Alzheimer disease-like pathology in mice.

Medeiros R, Kitazawa M, Passos GF, Baglietto-Vargas D, Cheng D, Cribbs DH, LaFerla FM.

The bradykinin B1 receptor regulates Aβ deposition and neuroinflammation in Tg-SwDI mice.

Passos GF, Medeiros R, Cheng D, Vasilevko V, Laferla FM, Cribbs DH. 

The role of PKC/ERK1/2 signaling in the anti-inflammatory effect of tetracyclic triterpene euphol on TPA-induced skin inflammation in mice.

Passos GF, Medeiros R, Marcon R, Nascimento AF, Calixto JB, Pianowski LF. 

Probucol affords neuroprotection in a 6-OHDA mouse model of Parkinson's disease.

Ribeiro RP, Moreira EL, Santos DB, Colle D, Dos Santos AA, Peres KC, Figueiredo CP, Farina M.

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